Every computer user needs to consider the best ergonomic mouse for wrist pain, along with ergonomic keyboards.

Instead of suffering from the effects of overextension and carpal tunnel, ergonomic peripherals are essential.

There are plenty of mouse options on the market, but we’ve found five top-rated designs to consider.

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Best Ergonomic Mouse for Wrist Pain Reviews

1. Anker 2.4G Wireless Vertical Ergonomic Optical Mouse

The Anker 2.4G Wireless Vertical Ergonomic Optical Mouse is designed to keep your wrist in its natural position.

With a scientifically-backed ergonomic design, it helps to alleviate wrist and hand fatigue after hours of clicking.

With a unique style, it’s one of the better options for overall wrist health.

Review

Let’s get into the best features of the Anker 2.4G Wireless Vertical Ergonomic Optical Mouse that make it a phenomenal vertical mouse.

• Ergonomic Design

The main feature that makes this mouse highly competitive is its scientific ergonomic design.

Your wrist will be kept in a neutral handshake position when in use.

This helps to ensure every movement is fluid and natural with less physical strain.

• Optical Tracking Technology

If you’re tired of using low-quality peripherals with poor sensitivity, this model is a massive upgrade.

Optical tracking technology in the mouse is available at 800, 1200, and 1600 DPI for customizable sensitivity.

Its tracking is improved, offering preciseness and smoothness on all surfaces.

• Next/Previous Buttons

On the side of the mouse, you’ll find two small programmable buttons that can make everyday computer actions simpler.

With the next/previous buttons, you can easily navigate the web or bind the keys in computer games for a seamless experience.

They’re highly beneficial for more convenience.

• Power-Saving Mode

As the Anker 2.4G Wireless Vertical Ergonomic Optical Mouse is wireless, it works on two AAA batteries.

The mouse enters a power-saving mode when not in use for eight minutes.

To exit this mode, simply click the right or left button to wake it from the sleep cycle.

• 2.4G Receiver

This model is an upgrade if you’ve used a wireless mouse and found a poor connection to your computer.

With a 2.4G receiver, you’ll have considerably less input lag than with lower-quality wireless peripherals.

• Customizable Settings

When it comes to making your new mouse your own, you’ll want to be able to unlock customization options.

With this mouse, you can change the mapping of buttons with the Anker downloadable software.

Also, with the ability to change the DPI, you can find the perfect sensitivity level for your needs.

• Built-in Thumb Rest

This model is highly competitive compared to other ergonomic mice because of its overall design.

It features an added thumb rest while keeping your wrist in a neutral position.

This helps to keep your thumb comfortable for hours of extended use.

• Hassle-Free Warranty

When you buy new computer peripherals, it’s always essential to ensure a warranty covers you.

This model is covered 18 months after purchase, allowing you to get repairs or replacements as needed.

Since it’s hassle-free, you likely won’t have to offer huge explanations as to why the mouse needs repairs.

2. HOTWEEMS D-09 Wireless Mouse

The HOTWEEMS D-09 Wireless Mouse has a similar design to most gaming mice but also boasts a few ergonomic features.

With exceptional DPI options, customizable mapped buttons, and a sleek style, it’s great for any office.

Also, it comes in a variety of colorways ranging from black to purple.

Review

Let’s jump into the highlights of the HOTWEEMS D-09 Wireless Mouse.

• Advanced Ergonomics

Using a horizontal mouse for an extended period can be challenging to combat physical strain.

Using this mouse, you’ll have a 30-degree neutral handshake angle, keeping your wrist in an optimal position.

It has integrated contoured grips, making it easier for your hand to fit into the mouse comfortably.

• Improved Wireless Transmission

This model also features wireless connectivity like the previous mouse we reviewed.

Similarly, it contains a 2.4G transmitter which helps to reduce most types of interference.

In addition, you’ll find a USB receiver to plug into your computer, making an effortless connection.

• Reduced Hand Movements

With the customizable DPI settings, you can tailor your new computer mouse to your every need.

Users can choose between 800 and 2400 DPI, akin to most gaming mice.

With the addition of the high-precision sensor, you’ll need to make fewer hand and wrist movements, reducing your fatigue.

• Single Battery Required

Instead of investing hundreds of dollars into batteries over the lifespan of your mouse, this model is more efficient.

It requires one AA battery, which can last up to 16 months with regular use.

• Sleep Mode

To help you preserve important battery life, this model comes with an automatic sleep mode.

When the mouse is idle for eight minutes, it immediately powers down and can be woken by clicking a button.

• Durable Design

Finding an ergonomic mouse that’s both comfortable and made to last over the years can be challenging.

With the HOTWEEMS D-09 Wireless Mouse, you’ll have up to 50,000,000 clicks before needing a replacement.

• Versatile Compatibility

Gone are the days when you would need to buy specific peripherals for different operating systems and hardware.

With this mouse, you’ll find it works equally efficiently on Chromebooks, MacBooks, and PCs. 

• Compact Design

You’re likely to find this mouse is comfortable for most hand sizes, but it’s also a great option for travel.

If you’re a student searching for an easy-to-store mouse that you can use in class, this design is your best choice.

With its compact style, it’s phenomenal for use anywhere.

• Smooth Gliding

Looking at the bottom of the HOTWEEMS D-09 Wireless Mouse, you will find three smooth patches.

These patches help the mouse glide effortlessly across multiple types of surfaces.

Instead of the bottom snagging on your mousepad, you’ll find it moves with less effort.

• Rubberized Coating

If a secure grip is what you’re looking for in your new mouse, this model is ideal.

The premium rubberized coating is easy to clean and feels comfortable against the skin.

It also helps you maintain your grip with far less effort.

3. Logitech MX Master 3S Wireless Performance Mouse

Logitech is one of the front runners in developing high-quality computer peripherals.

With the Logitech MX Master 3S Wireless Performance Mouse, you can transform your everyday comfort while at work or casually browsing the internet.

It has plenty of top-tier features that impress experienced computer users.

However, if you’re upgrading from the MX Master 3, know that the 3S only offers two easily distinguishable upgrades.

We’ll talk about them in a jiffy.

Review

Let’s look at the highlights of the Logitech MX Master 3S Wireless Performance Mouse.

• Any-Surface Tracking

A unique feature of this mouse is that it offers exceptional tracking on absolutely any surface.

Instead of investing in a mousepad, you’ll be able to grab and go with this model.

It’s even designed to work seamlessly on glass desktops without requiring anything underneath.

• Upgraded DPI Sensor

This model is the right option if you’re looking for a top-rated mouse that allows for ample DPI customization.

It boasts 8K DPI, allowing you to manage the sensitivity of your cursor up to 8000.

This is considerably faster than most other standard mice and gaming mouse models.

The 8K DPI is the first of the two upgrades from the MX Master 3, which only offers 4000 DPI.

• Quiet Clicks

Working in a quiet office can be frustrating when all you hear is clicking throughout the day.

With the Logitech MX Master 3S Wireless Performance Mouse, you can reap the benefits of a quieter working environment.

The left and right mouse buttons on the MX Master 3 have noticeable clicking sounds, whereas the 3S boasts ultra-silent clicking.

With Quiet Clicks, you get the same satisfying feedback from your mouse but with up to 90% less noise compared to the MX Master 3.

• MagSpeed Scrolling

There’s nothing worse than spending too much time navigating spreadsheets and web pages.

This mouse features MagSpeed scrolling, which is approximately 90% faster than your average mouse.

You’ll also find the scroll wheel is exceptionally quiet and allows for up to 87% more precision when scrolling.

• Ergonomic Design

Considering you’re on the hunt for the best ergonomic mouse, it’s important to note the design of this model.

The Logitech MX Master 3S Wireless Performance Mouse is designed to be comfortable all day, regardless of how you move your wrist.

The silhouette allows for natural wrist posturing, and the thumb controls are perfectly placed for reduced movement.

• Customizable Software

Have you ever used a mouse in the past and wondered why you weren’t able to map specific buttons outside of a gaming environment?

With this model, you can now fully customize your mouse’s buttons using Logi Options+.

Users can create multiple profiles with different button layouts, helping to streamline their workflow.

• FLOW Control

Another incredibly unique feature of this mouse is its FLOW cross-computer control.

Interestingly, you can use the same mouse across different computers and laptops, allowing you to transfer files and images seamlessly.

This feature is currently only available on Windows and macOS computers and tablets.

• Multi-Connectivity

The Logitech MX Master 3S Wireless Performance Mouse uses Bluetooth to pair with your computer.

You can connect up to three devices simultaneously using this channel.

Alternatively, there’s a Logi Bolt USB receiver included that you can plug into your computer.

• Rechargeable

The Logitech MX Master 3S Wireless Performance Mouse helps to take the stress out of having a dead or dying mouse.

Instead of having to keep a collection of batteries on-site, you simply recharge the device in your computer.

There’s an included USB-C cable that you can use to keep it at full battery every day. 

4. Logitech ERGO M575 Wireless Trackball Mouse

The Logitech ERGO M575 Wireless Trackball Mouse is one of their best models designed specifically for ergonomics.

Its unique design is reminiscent of the early 2000s, which makes it a remarkable thing to display on your desk.

Its compatibility for both Windows and Mac makes it a convenient tool for your professional and casual setups.

Review

Let’s check out the fascinating features of the Logitech ERGO M575 Wireless Trackball Mouse.

• Sculpted Ergonomic Design

When looking at this mouse for the first time, it’s easy to see how it was designed for the everyday user in mind.

Its sculpted body is specifically created to help relax your hand and arm throughout the day.

Also, its natural contouring fits comfortably in your hand, helping to reduce additional strain.

• Smooth Thumb Features

The smooth thumb features on the Logitech ERGO M575 Wireless Trackball Mouse are another unique concept.

On the side of the mouse, you’ll find a large blue ball you can reach with your thumb.

This component is your scroll wheel and works smoothly, offering precise scrolling as needed.

• Improved Cursor Control

The general smoothness of this mouse is another feature to make a note of.

It glides effortlessly across most surfaces, allowing you to optimize your movements.

Additionally, you can adjust the cursor settings using the Logitech Options downloadable software.

• Dual Connection Options

If you’re not a massive fan of using Bluetooth when connecting your peripherals to your computer, this mouse can help.

It features a USB receiver that you can quickly plug into your Mac or Windows laptop or computer as needed.

Alternatively, you can use Bluetooth connectivity, which gives you up to 33 feet of range.

• Non-Adjustable DPI

An adjustable DPI would have made this mouse one of the more competitive models on the list.

However, it has a nominal setting that you cannot change directly on the mouse.

As such, it’s an excellent option for everyday computer tasks but isn’t ideal if you want faster movements.

• Recycled Plastic Parts

With the planet’s health in mind, the Logitech ERGO M575 Wireless Trackball Mouse is an excellent addition to your office.

All the plastic parts in the mouse are crafted using post-consumer recycled plastic.

The graphite/black model uses 50% recycled plastic, and the off-white model contains 21%.

• Single AA Battery

Unfortunately, this mouse isn’t designed to be recharged, which is typical for most average working mice.

For power, you will need to provide one AA battery.

This mouse is highly competitive because a single battery can last up to two years, depending on how often you use your mouse.

• Back/Forward Buttons

The back and forward buttons are two added features to this model that make it helpful for office environments.

Conveniently located near the left-click button, you can easily navigate between two pages simultaneously.

It can also assist with browsing documents, limiting wrist movements, and saving time.

5. Logitech Lift Vertical Ergonomic Mouse

Modern, sleek, and high-tech are the three words that remind us of the Logitech Lift Vertical Ergonomic Mouse.

This model offers plenty of benefits, especially if you need an ergonomic mouse for your computer.

As an added benefit, you can choose from left or right-handed models as needed.

Review

Let’s get into the best highlights of the Logitech Lift Vertical Ergonomic Mouse.

• Great Fit for Most

If you have particularly large hands, you’ll want to consider finding an alternative ergonomic mouse.

This model is crafted for small to midsize hands, making it easy for the mouse’s center to fall into the middle of your palm.

You may find it sits uncomfortably with too large hands, preventing a neutral wrist posture.

• Improved Coziness

Cozy might not be a term you’d think of when shopping for a mouse, but this model can impress.

The built-in wrist helps to lift your wrist comfortably to a healthy position during the day.

Also, there’s a uniquely snug rest for your thumb to remain while computing, adding to its overall comfort.

• Soft Textured Grip

One of the most important, often overlooked, features when shopping for a mouse is its material.

You’ll want a model that feels comfortable against the skin and helps you maintain your grip.

The Logitech Lift Vertical Ergonomic Mouse has a soft textured grip, which feels and works great.

• 57-Degree Ergonomic Position

The Logitech Lift Vertical Ergonomic Mouse features anatomically-correct ergonomics for all users.

With the vertical shape of the mouse, your wrist will be in a more natural posture from the forearm.

It’s a fantastic upgrade from a standard mouse, helping alleviate carpal tunnel discomfort.

• Cordless Design

This is one of the top models to consider if you’re hunting for a wireless mouse.

Its wireless connectivity options are highly reliable, whether you use Bluetooth or the included USB dongle.

You’ll also find it easily connects to Windows and macOS as needed.

• Tablet-Compatible

With modern improvements to tablets, they’re becoming more and more like laptops as time progresses.

As such, you may want to consider investing in peripherals to make your portable computer-like tablet accessible.

This mouse is fully designed to work with Chrome OS, iPad OS, Android, and Linux, adding to its versatility.

• Low-Energy Connectivity

Fortunately, the Logitech Lift Vertical Ergonomic Mouse doesn’t require replacement batteries to work.

Instead, it’s fully rechargeable and offers an extended battery life per charge.

Using modern low-energy connectivity, your mouse could last up to two years before needing a recharge.

• Customizable Buttons

Creating your own tailored mouse has never been simpler than with the Logitech Lift Vertical Ergonomic Mouse.

You can easily download the Logitech software to customize the mapping of your buttons as needed.

Setting up different profiles is also easy, helping you streamline your daily workflow.

• Whisper-Quiet Clicks

The Logitech Lift Vertical Ergonomic Mouse is a fantastic upgrade from loud and low-quality peripherals.

 Instead of an annoying clicking sound throughout the day, you’ll find this mouse is whisper quiet.

It’s an excellent upgrade for yourself or your employees.

• SmartWheel Scrolling

You’ll fall in love with the intuitive design of the SmartWheel on this mouse.

This mouse feels natural, allowing you to scroll down pages and documents effortlessly.

With this level of ingenuity, you’ll find scrolling can take significantly less time.

• Logitech FLOW

One of the more unique features of this mouse is that it’s compatible with Logitech FLOW technology.

With FLOW, you can switch between different computers using the same mouse.

It’s a phenomenal way to streamline your workflow, allowing you to transfer documents and photos in seconds quickly.

Which Is the Best Mouse for Wrist Pain?

The Logitech MX Master 3S Wireless Performance Mouse is our choice for the best ergonomic mouse for wrist pain.

Not only is it packed with many high-end features, such as magnetic scrolling and customizable DPI settings, but it also looks fantastic.

With a style that is sure to adapt to your everyday working needs, it’s by far the best option for hand and wrist fatigue.